EINZ Research

Research & Development

Innovation at the frontier of ECMO and critical care

Cardiac Transplantation International Collaboration Announcement Coming

HeartBridge: A New Chapter in Cardiac Transplantation

What if the greatest constraint in heart transplantation — time — could be removed entirely? EINZ is preparing to showcase a technology in collaboration with international partners that we believe will fundamentally change what is possible in cardiac transplantation. Details to follow.

01

Coming to New Zealand

Heart transplantation is one of medicine's most life-saving interventions — and one of its most constrained. The barriers are not primarily biological. They are logistical, geographic, and time-dependent. We are approaching a moment when those barriers may be lifted in a way that was not previously considered possible.

EINZ will be presenting a technology at our upcoming conference in New Zealand that addresses the fundamental limitation at the heart of cardiac transplantation. We are not yet in a position to share full details, but we can say this: the implications for donor availability, recipient access, surgical planning, and long-term outcomes are substantial.

For those attending the conference, this will be a centerpiece presentation. For those who cannot join us in person, full information will be published here following the event.

Save the date

EINZ International Conference
New Zealand

Full program, registration, and venue details at the conference website.

Conference details ↗
MR / AR Ultrasound 2 Publications

AR Ultrasound: Mixed Reality-Guided Procedures

Examining the impact of MR and AR-guided ultrasound on procedural performance, safety, teaching, remote supervision, and workspace ergonomics — with Apple Vision Pro as the primary platform.

01

Overview

Ultrasound-guided vascular access offers well-established advantages over landmark-based techniques: lower first-attempt failure rates, faster time to success, and fewer complications. It is hence globally the gold standard. Yet a persistent ergonomic problem undermines its full potential. The procedure site and the visual display are spatially discrepant, forcing clinicians to divide attention between patient and screen.

The program investigates whether mixed reality and augmented reality head-mounted displays can eliminate this disconnect by unifying the ultrasound image within the operator's direct field of view. We are examining performance, safety, teaching efficiency, remote supervision, and workspace ergonomics across simulation and clinical settings.

Our initial work focused on passthrough augmented reality via Apple Vision Pro — a binocular, wireless, standalone device offering state-of-the-art video see-through capabilities. Unlike monocular or optical see-through HMDs, this approach avoids image degradation from real-world lighting conditions and resolution limitations.

Our published study was conducted at an international ECMO symposium, recruiting vascular access experts including anesthesiologists, intensivists, and cardiac surgeons. A second study has been submitted for publication.

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Publications

Virtual Ultrasound-Guided Central Vascular Access Using Apple Vision Pro: An Evaluation and Proof of Concept

Bexten T, Boehm A, Miller J, Yalamuri SM, Read MD, Simard T, Wiebe S.

Cureus · July 2025

doi:10.7759/cureus.87274 · PMID: 40755649 · PMCID: PMC12318436

Published

Augmented Reality Ultrasound-Guided Vascular Access via Apple Vision Pro

Miller J, Bexten T, Wiebe S, Read MD, Simard T, Yalamuri SM.

BMC Proceedings · Submitted

Submitted
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Research Dimensions

Performance

Procedural Accuracy

First-attempt success rates, time to access, and complication rates in AR-guided vs. standard ultrasound conditions across novice and expert operators.

Safety

Error Reduction

Spatial unification of visual inputs reduces the cognitive load associated with switching between patient and screen — a documented source of procedural error.

Education

Teaching & Supervision

AR enables real-time remote supervision and shared visual fields, opening new models for procedural training and expert tele-guidance.

Ergonomics

Workspace Design

Eliminating the ultrasound cart from the workspace has significant implications for room layout, sterile field management, and operator comfort during prolonged procedures.

Future direction

Probe Integration

Current probes are not designed with AR in mind. Spatially registered, probe-integrated AR with on-probe controls represents the key next engineering milestone.

Active

Clinical Translation

A clinical trial is currently underway. Recruitment is expected to begin in 2026, extending the work from simulation and animal model settings into ICU and operating room environments.

ECPR Support Active Development

Sessions App: Intelligent ECPR Timestamping & Protocol Generation

A real-time procedural support platform for ECPR cannulation — automating timestamps, streaming a live summary to the resuscitation bay, and building towards AI-generated protocols and outcome prediction.

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The Problem

Extracorporeal Cardiopulmonary Resuscitation (ECPR) is a high-acuity, time-critical procedure performed under extreme cognitive load. Accurate contemporaneous documentation is nearly impossible during active cannulation, yet the resulting procedural record is essential for clinical governance, handover, and outcome analysis.

Situational awareness is a broader challenge than it first appears. Team members already present become task-focused and are at risk of losing the bigger picture: what has happened, in what sequence, how long has elapsed, and what decisions have already been made.

Sessions addresses this across multiple levels simultaneously. By automating timestamp capture and streaming a continuously updated scenario summary to a large display in the resus bay, it removes documentation burden from the team and maintains a shared situational reference for everyone present.

Looking further ahead, integrating real-time outcome prediction scores introduces the ability to support patient selection decisions during active ECPR. The platform is currently deployed in our simulation program, with a pathway to clinical implementation under development.

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Core Capabilities

Live

Automated Timestamping

Every procedural event is time-stamped automatically during cannulation — no manual input required. A complete, accurate log is generated without cognitive overhead.

Live

Resus Bay Display

Sessions streams a real-time scenario summary to a large screen in the room — providing instant situational awareness for anyone entering, reducing handover risk.

Live

Protocol Generation

At the end of cannulation, the app automatically compiles the timestamped event log into a structured protocol ready for clinical records and governance review.

Near-term

ECMO PAL Integration

Collaboration with the ECMO PAL team (Monash University) to integrate real-time survival prediction via deep neural network during active ECPR.

Research horizon

AI Protocol Generation

Moving beyond timestamping: AI-registered awareness of procedural events — the system recognizes what is happening and generates the protocol autonomously.

Research horizon

Simulation Integration

Currently used in simulation scenarios — providing a closed-loop feedback environment for training teams and capturing performance data for iterative improvement.

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Collaborations

ECMO PAL — Monash University

Deep neural network-based survival prediction for venoarterial ECMO. Sessions will integrate ECMO PAL's real-time outcome prediction engine to surface survival probabilities during active ECPR procedures. ecmo-pal.icu ↗

Stephens AF, Šeman M, et al. ECMO PAL: using deep neural networks for survival prediction in VA-ECMO. Intensive Care Med. 2023;49(9):1090–1099. doi:10.1007/s00134-023-07157-x

Occasional Research Recruiting

The VinOx Study: ECMO Oxygenator-Assisted Wine Decanting

A fully rigorous, ethically approved, and entirely serious scientific investigation into whether hollow-fiber oxygenator membranes represent the future of wine decanting. We are ECMO specialists. This is what we do on weekends.

Study context This is genuine research with a real methodology, testable hypotheses, and outcomes we intend to publish. It also happens to be the most enjoyable IRB submission our department has ever filed.
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Hypothesis

Conventional wine decanting serves two purposes: aerating the wine to develop aroma and soften tannins, and separating it from sediment. What it does not do — and cannot do — is address lead contamination leached from the decanter itself.

Lead crystal decanters, long favored for their optical properties, release measurable quantities of lead into wine during storage and even brief contact. This has been documented since the early 1990s: Graziano & Blum (1991) demonstrated significant lead transfer from lead crystal into port wine within hours.

The VinOx hypothesis is straightforward: passing wine through an ECMO hollow-fiber oxygenator circuit simultaneously aerates the wine — achieving in minutes what conventional decanting requires hours to accomplish — while routing it through a lead-free medical-grade membrane system. Whether the membrane might also exert a filtration effect on dissolved lead already present in the wine is an intriguing secondary question.

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Scientific Rationale

Science, at its best, does not restrict itself to the merely urgent. Some of the most cited methodological contributions in medicine emerged from questions that initially seemed frivolous — and turned out not to be. The VinOx study has a real methodology, a testable hypothesis, and a finding with genuine translational potential. It also showcases the intellectual range of an ECMO program comfortable enough in its own expertise to ask: yes, but what about wine?

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Status

Phase 01 — Recruiting

Participant Enrollment

Seeking volunteers willing to consume wine in the name of science. Eligibility criteria: appreciation of Bordeaux; tolerance for questions about tannins.

Phase 02 — Planned

Data Collection

Blinded sensory panel evaluation, lead particle analysis, and oxygenation measurements across circuit configurations.

Phase 03 — Planned

Manuscript & Submission

Analysis, write-up, and submission to an appropriate journal. We anticipate peer review to go smoothly.

References

Graziano JH, Blum C. (1991). Lead exposure from lead crystal. Lancet, 337(8734), 141–142. doi:10.1016/0140-6736(91)90803-w. PMID: 1670790

Pisaniello DL, Brown AM. (1988). Lead-crystal decanters — a health risk. Medical Journal of Australia, 148(9), 484. doi:10.5694/j.1326-5377.1988.tb139590.x. PMID: 3362091